Jorge Pincay ’20 Low carbohydrate diets (LCD) have been adopted by many patients as a means of battling diseases such as cancer, diabetes, obesity, and many other metabolic disorders. This type of diet is even widely used by the general population for maintaining and/or losing weight. However, not many studies have investigated the adverse health effects that may result from a sudden halt in carbohydrates … Continue reading Can a Reduction in Carbohydrate Consumption Produce Adverse Effects?
Jorge Pincay ’20 Phosphoglycerate mutase 1 (PGAM1) is a gene known to promote rapid tumor growth and invasiveness in several cancers, including non-small cell lung cancer (NSCLC). PGAM1 encodes for an enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate in the glycolytic pathway, a compound that coordinates anabolic biosynthesis. In many forms of cancer, including NSCLC, urothelial bladder cancer, and hepatocellular carcinoma, upregulation of … Continue reading Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase
Jorge Pincay ’20 Over the years research in neuroscience has led to the development of brain implants, called microelectrodes that can help restore essential motor and sensory functions. This technology has become beneficial for those that suffer from head injury and neurodegenerative disease. The limitations of this technology lie within the immunological response that comes about shortly after implantation. This immune response, which is governed … Continue reading New Chemical Compound to Reduce the Adverse Side Effects of Neural Implants
Jorge Pincay ‘20 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that results in the degradation of nerve cells in the brain over time. This disease is the result of a DNA mutation — a cytosine-adenine-guanine (CAG) trinucleotide repeat expansion– that occurs in the gene that encodes for the huntingtin (Htt) protein. This repeat expansion causes a highly toxic form of the Htt protein … Continue reading The Use of Focused Ultrasound for Enhanced Delivery of Gene Therapy Across the Blood-Brain-Barrier
Jorge Pincay ‘20 Critical limb ischemia (CLI) is a cardiovascular condition characterized by severely narrowed arteries resulting from the buildup of plaque. This narrowing of the arteries significantly reduces blood flow to the hands, feet, and legs and may lead to amputation of the affected limbs. Most patients suffering from CLI need to undergo some form of a revascularization procedure in order to combat this … Continue reading Enhanced mRNA Gene Therapy for Critical Limb Ischemia