Author: Young Investigators Review

The Young Investigators Review is Stony Brook University's undergraduate-oriented, all-inclusive science journal. Founded in 2008, our mission is to provide the student community with a way to learn more about the research currently being done on-campus by their faculty and fellow peers. We feature articles that span all fields, from Physics to Neuroscience, as well as original student research reports straight from the campus laboratories. Our journal offers aspiring talented future researchers and physicians a way to hone their science writing skills and spread word of their experiences to inspire incoming students to think about devoting their futures to the various fields of science.
2016-17, Health, Medicine and Physiology

Improving Influenza Vaccine Efficacy Sans Adjuvants

    By: Richard Liang 18’ Vaccination is one of the best methods to guard against influenza, as it allows human dendritic cells (DCs) to promote long-term adaptive immunity. Due to the rapid pace of influenza mutation, the composition of influenza vaccines varies annually, with a focus on immunogenicity as opposed to vaccine efficacy. To improve efficacy, immunological agents known as adjuvants can be added … Continue reading Improving Influenza Vaccine Efficacy Sans Adjuvants

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2016-17, Genetics, Health, Medicine and Physiology

Using SIRT1 Activators to Treat Tuberculosis

    By: Richard Liang 18’ Tuberculosis (TB) is a highly infectious disease that can remain dormant for many years. Currently, treatment options are limited by Mycobacterium tuberculosis’s ability evade the immune system and mutate into drug-resistant strains. Outbreaks are a more pressing concern in developing countries, where health care is less accessible. In a recent study led by Catherine Y. Cheng from the Singapore … Continue reading Using SIRT1 Activators to Treat Tuberculosis

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2016-17, Biology, Engineering, Genetics

The Importance of Synthetic Core Promoters in Yeast Fine-Tuning Expression

    By Caleb Sooknanan ‘20 In genetic engineering, metabolic pathways and genetic circuits can be manipulated in microbes to produce chemicals or activate certain functions. To do this, gene expression must be fine-tuned to balance and optimize protein levels of metabolic enzymes or regulators.  Manipulating these in unicellular eukaryotes often involves core promoter sequences, the minimal portion of the promoter required to initiate DNA … Continue reading The Importance of Synthetic Core Promoters in Yeast Fine-Tuning Expression

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2016-17, Medicine and Physiology, Pharmacology

Peptide Microarrays Can Identify Tuberculosis Antibody Responses

  By Caleb Sooknanan ’20 Tuberculosis (TB) is the world’s most prominent cause of death by infection. Scientists have become increasingly interested in the humoral immune responses associated with TB, but it is difficult to find the antigenic targets that correspond to specific stages of TB infection and disease. Dr. Davide Valentini and researchers at Karolinska Institutet conducted a study to determine whether peptide microarray … Continue reading Peptide Microarrays Can Identify Tuberculosis Antibody Responses

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2016-17, Engineering, Health, Medicine and Physiology

Photocurable Bioinks and 3D-Printed Hydrophilic Drugs

  By Caleb Sooknanan ’20 Pharmaceutical dosages are often defined as the amount of active pharmaceutical ingredient (API) that has a therapeutic effect in the most patients. Using such a generalized method does not account for variations in patient genomic and pathophysiological status, leading to potential negative side-effects. Personalized medicine intends to provide patients with more individualized API concentrations in their prescriptions. However, changes in … Continue reading Photocurable Bioinks and 3D-Printed Hydrophilic Drugs

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2016-17, Evolution, Genetics

Relearn Faster and Retain Longer

    By Ericka Berman As established, repetitive practice is necessary for knowledge retention. Sleep is also a contributing factor to new learning and memory consolidation. In this study, Dr. Mazza and the team of researchers recruited 40 participants ages 18-29 from University of Lyon, who were randomly assigned to one of two groups. For this study, participants were asked to remember 16 Swahili-French words pairs. … Continue reading Relearn Faster and Retain Longer

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Hnery Ng
2016-17, Biology, Interview

Interview with Student Researcher Henry Ng

This past month, one of our cabinet members, Benjamin Kerner, had the opportunity to sit down with Henry Ng, a prominent student researcher here at Stony Brook. B: Alright so first question, what is your name, major, and department? H: I’m Henry Ng, and I’m a Biology major, specializing in developmental genetics. I am also a chemistry minor, because chemistry is great. I love it. … Continue reading Interview with Student Researcher Henry Ng

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Figure 1. Mammalian brains can be influenced by non-genetic and Allele-Specific expression
2016-17, Genetics, Health, Medicine and Physiology

Sending Your Grandparents to University Increases Cognitive Reserve: The Tasmanian Healthy Brain Project

By Ericka Berman   One way to decrease the likelihood of Alzheimer’s disease is by increasing cognitive reserves (CR). Research supports the idea that education, intelligence, and cognitively stimulating activities modify the risk for dementia. CR is a theoretical construct, so it is measured indirectly. Dr. Megan Lenehan and her team of researchers used data from 459 participants ages 50-79 from the Tasmanian Healthy Brain Project … Continue reading Sending Your Grandparents to University Increases Cognitive Reserve: The Tasmanian Healthy Brain Project

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2016-17, Genetics, Psychology

Creating Birds of Similar Feathers: Leveraging Similarity to Improve Teacher-Student Relationships and Academic Achievement

By Ericka Berman   Having thriving student-teacher relationships (TSR) is important in academic success. In studying the improvement of TSR, schooling, positive youth development, and social motivation are of great interest to researchers. Dr. Hunter Gehlbach and his team of researchers carried out this study using a sample of 315 ninth graders and 25 teachers from a high school in the southwestern United States. Students were … Continue reading Creating Birds of Similar Feathers: Leveraging Similarity to Improve Teacher-Student Relationships and Academic Achievement

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Figure 1. Mammalian brains can be influenced by non-genetic and Allele-Specific expression
2016-17, Biology, Genetics, Neuroscience

Mammalian Brain Affected by Non-Genetic and Allele-Specific Expression

By Rideeta Raquib ’19 The brain is a complex organ that is constantly being impacted by genetic and epigenetic factors. Mental illness patients are usually heterozygous in terms of inheriting one mutant allele. The random inactivation of the X-chromosome and genomic imprinting influences brain architecture and risk of disease. Studies on neuropsychiatric disorders uncovered a spectrum of data regarding the epigenetic dynamics of such dysfunction. … Continue reading Mammalian Brain Affected by Non-Genetic and Allele-Specific Expression

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Figure 1. Consumers view all-natural products more positively despite no formal definition existing for the term.
2016-17, Sociology

The “All-Natural” Marketing Label and its Effect on Consumers

By Megan Tan ’19 The “All-Natural” label is extensively used to market consumer products. However, this label is not regulated or defined by the Food and Drug Administration (FDA) since it is deemed a marketing label to influence consumers’ purchases. As such, little research has been done to analyze the effect that that label has on consumers’ perceptions of “all natural” food quality, nutritional content, … Continue reading The “All-Natural” Marketing Label and its Effect on Consumers

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Figure 1. Liraglutide 3·0 mg may reduce the risks of type 2 Diabetes.
2016-17, Health

Reduction of Type 2 Diabetes Via Weight Loss Drug

By Rideeta Raquib ’19 Prediabetes, also known as “borderline diabetes,” is a condition common among people with obesity who have increased blood sugar levels. Although it can eventually lead to type 2 diabetes, prediabetes can be cured through exercise and diet changes. In 2012, 86 million Americans of age 20 years or older had prediabetes. A drug, named Liraglutide 3·0 mg, can reduce body weight … Continue reading Reduction of Type 2 Diabetes Via Weight Loss Drug

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