Category: Biology

2016-17, Biology

Phantom Limb Pain Caused by Sensorimotor Cortex Plasticity

by Patrick Yang ’20   Amputation or severe neural damage can trigger phantom limb pain, chronic pain felt in a limb that is no longer present. Phantom pain, which is associated with a burning or hypersensitive sensation, has a wide range of duration – it can be as short as a few minutes or as long as a couple days. According to popular theory, maladaptive plasticity … Continue reading Phantom Limb Pain Caused by Sensorimotor Cortex Plasticity

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2016-17, Biology

A Newly Discovered Function of Cyclin A2, a Major Regulator of Cell Cycle Progression in Tumors

by Jalwa Afroz ’17   Regulation of the cell cycle is crucial to maintain appropriate cell growth, proper chromosome replication and segregation. Cyclin A2 is one of the many cell cycle regulators that activate cyclin-dependent kinases, Cdk1 and Cdk2, which form Cyclin A2-cdk complexes that activate transcription of DNA replication factors that promote progression through the cell cycle. Conditional cyclin A2 knockout mice revealed the … Continue reading A Newly Discovered Function of Cyclin A2, a Major Regulator of Cell Cycle Progression in Tumors

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2016-17, Biology, Medicine and Physiology

Gold Nanoparticles Suppressing Tumor Growth in Pancreatic Cancer

by Rideeta Raquib ’19   Gold is one of the most valuable resources in the world, and its value may be even greater due to its potential as a new treatment for pancreatic cancer. Previously, gold nanoparticles, AuNPs, were used to target tumor regions and aid in the transport of drugs and chemotherapy to the tumor.  A previous study showed that gold nanoparticles had the ability … Continue reading Gold Nanoparticles Suppressing Tumor Growth in Pancreatic Cancer

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2016-17, Biology

Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry

by Jalwa Afroz ’17   The human immune system, varying amongst individuals from different populations, evolved under selective pressure from pathogenic environments. Genome-wide association studies (GWAS) have shown extreme differences in allele frequency between various human populations for infectious, autoimmune, and inflammatory diseases. Additionally, expression quantitative trait locus (eQTL) mapping studies in antigen-exposed immune cells have identified hundreds of genetic variants that also explain variation … Continue reading Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry

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2016-17, Biology

Frog Skin Contains Chemicals That Repel Ants

by Rideeta Raquib ’19   Several species, such as the Lutjanus bohar fish species, have the ability to camouflage themselves to avoid predators. This allows them to have a selective advantage in their respective environments compared to other species. Dr. Andre de Lima Barros, from the National Institute of the Amazonian Research in Brazil, hypothesized that Lithodytes lineatus, a species of frog prominent in the Amazon … Continue reading Frog Skin Contains Chemicals That Repel Ants

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2016-17, Biology

Effects of Neutrophil production on tumor metastasis

by Richard Liang ’18   The term “cancer” comprises various diseases involving abnormal cell growth. They become most dangerous after metastasis, when they spread to multiple organs. Though few treatments are currently available for cancers past this stage, a recent study led by Dr. Juwon Park in Cold Spring Harbor Laboratory has identified neutrophils, a type of leukocyte in the blood, as a potential therapeutic target … Continue reading Effects of Neutrophil production on tumor metastasis

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2016-17, Biology, Psychology

Hormonal Birth Control May Lead to Depression

by Patrick Yang   Approximately 62% of women aged 14-44 in the U.S. are using a method of contraception, and 27% of those women are using hormonal contraception, according to a National Health Statistics report. The key to hormonal contraception’s mass appeal lies in its convenience and reversibility; it can be found in pill or patch form and does not have permanent effects. However, the estrogen … Continue reading Hormonal Birth Control May Lead to Depression

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2016-17, Biology, Genetics, Health, Medicine and Physiology, Neuroscience

Memory and the Stages of a Women’s Menstrual Cycle

    by Rideeta Raquib Previous psychological studies have suggested that women have a good memory, but a new study implies that this may be due to the impact of hormones. Other studies that tested rodents showed that there was a correlation between low estradiol (E2) levels and an increase in striatal mediated response strategies. The striatum is a region of the forebrain associated with … Continue reading Memory and the Stages of a Women’s Menstrual Cycle

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2016-17, Biology, Medicine and Physiology

Stem Cells Successfully Generate a Fully Functional Liver

    by Rideeta Raquib Approximately 30 million people are affected by liver disease globally, and the quest to find donors for liver transplants is difficult. There is a lack of functional livers available compared to the liver disease patient population. In some cases, a portion of the liver from a living donor is sufficient for regular function. Stem cells are unspecialized cells that can differentiate … Continue reading Stem Cells Successfully Generate a Fully Functional Liver

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2016-17, Biology, Health, Medicine and Physiology

Visualizing Microbial Evolution on Antibiotic Landscape

By Jalwa Afroz Bacteria survive by evolving and reproducing in order to overcome environmental challenges. However, there is very little information available on how bacteria physically move in order to attain an environment that is suitable for their needs. Scientists from Harvard Medical School and Technion-Israel Institute of Technology have designed a simple way to show how bacteria move as they become resistant to drugs. … Continue reading Visualizing Microbial Evolution on Antibiotic Landscape

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2016-17, Biology, Health, Medicine and Physiology, Neuroscience, Psychology

‘Super-agers’ Retain Youthful Memories

  By Jalwa Alfroz As humans age, it is normal for cognitive skills, such as memory, to decline. However, some people seem to escape this fate, and are subsequently categorized as super-agers. Investigators at the Harvard-affiliated Massachusetts General Hospital, led by Dr. Bradford Dickerson, revealed that certain areas of the brains of older adults with extraordinary memory performance looked similar to those of young adults. Previously, … Continue reading ‘Super-agers’ Retain Youthful Memories

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2016-17, Biology

New Enzyme Responsible for Cell Mediated Death Identified

by Richard Liang   The human body has developed mechanisms to deal with genetically damaged cells before they can become a threat. One such mechanism occurs when DNA is excessively damaged. Cells undergo cell death mediated by an enzyme known as poly ADP-ribose polymerase-1 (PARP-1). However, in certain instances like a stroke, the PARP-1 pathway is overly activated, causing mass cell death in the body. … Continue reading New Enzyme Responsible for Cell Mediated Death Identified

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