Category: General Neuroscience

Cognition, General Neuroscience, Genetics

The Influence of Epigenetic Age on Cognitive Decline

 Julia Chivu ’23 As people age, their cognitive abilities tend to decline. While chronological age is commonly cited as a reason for this decline, it often fails to explain why some individuals have higher cognitive performance than others of the same age. To address this, epigenetic clocks, which analyze DNA methylation at specific genomic sites correlated with aging, are emerging as useful tools for predicting … Continue reading The Influence of Epigenetic Age on Cognitive Decline

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General Psychology, Neurology, Psychology

Quantifying Affectionate Touch in Romantic Relationships

Julia Chivu ’23 Across cultures and continents, affection serves as a universal bond that unites romantic partners. Researchers from various institutions worldwide collaborated on two studies to better understand and quantify the dynamic between love and touch. The first study sought to investigate the global association between love and touch-related behaviors. The second study examined the correlation between frequencies of affectionate touch and love amongst … Continue reading Quantifying Affectionate Touch in Romantic Relationships

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Brain, Drug Discovery, General Neuroscience, Health and Medicine, Neuroscience

AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

Vignesh Subramanian ’24 Figure 1: The South Pool of the 9/11 Memorial in New York, New York Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive thinking skills that typically worsens with age, and is the leading cause of dementia. Key hallmarks of the disease include buildups of two particular proteins – beta-amyloid peptide and phosphorylated tau – … Continue reading AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

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Biology, Brain, General Neuroscience

Chronic Pain Signaling Predicted by Orbitofrontal Cortex Signatures

Vignesh Subramanian ’24 Figure 1: A sagittal MRI view of the human orbitofrontal cortex. Chronic pain syndromes typically entail persistent pain lasting at least three months, marked by the long-term rewiring of neural circuitry that triggers unprompted pain signals. Measuring chronic pain has long proven challenging due to its entanglement with a wide array of overlapping neural circuits and the subjectivity with which it is … Continue reading Chronic Pain Signaling Predicted by Orbitofrontal Cortex Signatures

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Health, Neurology, Neuroscience, Psychology

Where Do We Feel Love?

Julia Chivu ‘ 23 Figure 1  A person looking off to the side while clutching a neon red heart in a dimly lit environment.  Love has compelled psychologists, philosophers, neuroscientists, and other scholars to try and understand its complexities and implications. Researchers from Aalto University sought to understand how 27 different types of love, including parental, romantic, sexual, and religious love, are perceived and experienced … Continue reading Where Do We Feel Love?

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Brain, General Neuroscience, Neurology, Neuroscience

PD-Modeling Midbrain Dopamine Loss Diminishes Thalamocortical Signaling

Vignesh Subramanian ’24 Figure 1: The substantia nigra (SN) nucleus in the midbrain. Parkinson’s disease (PD) is an age-related, neurodegenerative movement disorder that causes a progressive loss of motor control. The disease is characterized by a loss of dopaminergic (DA) neurons in the substantia nigra (SN), a midbrain nucleus that modulates movement and reward functions. The SN is one of five subcortical nuclei that make … Continue reading PD-Modeling Midbrain Dopamine Loss Diminishes Thalamocortical Signaling

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Neurology, Psychology

Maternal Empathetic Cortical Responses Synchronize with Neonatal Pain Perception

Vignesh Subramanian ‘ 24 Figure 1: The heel prick of an infant’s foot, which often induces momentary pain for the infant. The early psychophysical development of newborns relies heavily on having strong emotional bonds with caregivers. Compared to other animals, human infants are born highly dependent on their parents, undergoing a prolonged period of extensive neural organization and brain development that requires greater parental sensitivity … Continue reading Maternal Empathetic Cortical Responses Synchronize with Neonatal Pain Perception

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Neuroscience

Prairie Vole Monogamy: key in understanding neural underpinnings of love

Jessica George ’24 Figure 1 Prairie voles are small rodents known for their unusual monogamous behavior Love and attachment hold a very important place in human lives but the neuroscience behind them is poorly understood. Recent groundbreaking research involving prairie voles helped to unravel the biological mechanisms behind love and bonding. Prairie voles are small rodents known for their unusual monogamous behavior, forming long-term pair … Continue reading Prairie Vole Monogamy: key in understanding neural underpinnings of love

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Health and Medicine, Neuroscience

Nicotine exposure discovered to block aromatase activity in healthy women

Jessica George ’24 Figure 1 Nicotine use disorder has a profound impact on hormones, yet sex differences are poorly understood. Maintaining a harmonious sex-hormone balance is essential for the optimal functioning of the body, as it regulates a wide range of physiological processes. Aromatase serves as the critical enzyme responsible for the conversion of androgens into estrogens, a process fundamental to functions associated with emotional … Continue reading Nicotine exposure discovered to block aromatase activity in healthy women

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Brain, Neurology

Understanding the Neurobiology of Love and Deception

Julia Chivu ’23 Figure 1  Couple holding hands walking towards a multi-colored sunset Recent scientific research has been increasingly focused on better understanding the complex relationship between deception and love. The study of deception within relationships and across genders is essential for interpreting the correlation between human behavior, neural mechanisms, and trust. A research team from Zhejiang Normal University investigated the neurological mechanisms of deception … Continue reading Understanding the Neurobiology of Love and Deception

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Neuroscience

Radiation-Induced Cognitive Decline Impairs Hippocampal Neurogenesis

Vignesh Subramanian ’24 Figure 1: A radiograph captured by X-ray, which produces ionizing radiation, a form of radiation that poses risks of damage to internal tissue. Ionizing radiation is any radiation traveling in the form of electromagnetic waves or particles with enough energy to knock electrons out of the orbit of atoms. While therapies such as radiotherapy for cancer are intended to emit ionizing radiation … Continue reading Radiation-Induced Cognitive Decline Impairs Hippocampal Neurogenesis

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2022-23, Brain, Cognition, General Neuroscience, Neuroscience, Year

Microdosing Psychedelics

Shahzadi Adeena ’25 In recent years, there has been a growing interest in microdosing psychedelic drugs as a potential tool for enhancing cognitive abilities and improving overall wellbeing. Vince Polito and Richard J. Stevenson of Macquarie University investigated the effects of microdosing psychedelics on psychological variables such as mood, attention, wellbeing, mindfulness, mystical experiences, personality, absorption, creativity, and sense of agency. The researchers hypothesized that … Continue reading Microdosing Psychedelics

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