Category: Year

2022-23, Biology, Brain, Cellular and Molecular Science, General Neuroscience, Molecular Biology, Neurology, Neuroscience

Lack of CLOCK Regulator Protein May Predict Focal Seizure Susceptibility

By Vignesh Subramanian ’24 Focal seizure activity originates at particular foci﹣those being lobes, regions or hemispheres – of abnormal brain tissue and may emanate outward.  Epilepsy is a chronic central nervous system disorder characterized by uncontrolled electrical activity in the brain that triggers recurrent, spontaneous seizures. The majority of new epilepsy cases involve focal epilepsy, in which seizure activity originates in a particular “focus” or … Continue reading Lack of CLOCK Regulator Protein May Predict Focal Seizure Susceptibility

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2022-23, Artificial Intelligence, Biology, Genetics

Are Doppelgängers Really Just a Coincidence?

Lydia Wang ’26 Human faces and the ability to recognize different facial identities have played a key role in evolution. It has been observed that human faces have evolved to uniquely distinguish themselves from others. However, many people know someone they resemble; some comparisons are so similar that they are labeled as a doppelgänger, or a living double. Doppelgängers have been an ongoing phenomenon that … Continue reading Are Doppelgängers Really Just a Coincidence?

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2022-23, Biology, Health and Medicine, Neuroscience

Type 2 Diabetes Accelerates Brain Aging-Related Neurocognitive Decline

Vignesh Subramanian ’24 Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by dysfunctions relating to hyperglycemia, the state of high glucose levels in the bloodstream. Such excessive blood sugar is typically the combinatory result of inadequate secretion of insulin (a hormone that directs cells and the liver to take up glucose for energy and long-term storage, respectively), uncontrolled secretion of glucagon (an … Continue reading Type 2 Diabetes Accelerates Brain Aging-Related Neurocognitive Decline

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2022-23, General Psychology, Psychology

Anxiety Can Alter the Way We Perceive Negative Emotions

Lydia Wang ’26 As individuals, we constantly make decisions, many of which depend on our perception of social contexts. For example, when answering a question during class, one may gauge a friend’s expressions and observe whether they are grimacing or smiling, which (respectively) suggest an incorrect or correct response. This is an example of perceptual decision-making, where through observation and sensory input, one chooses an … Continue reading Anxiety Can Alter the Way We Perceive Negative Emotions

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2021-22, mental health, Psychology

Depression May Be Linked To Specific Lipid Ratios Within The Body

Joyce Chen ’23 Depression is a chronic disease that affects quality of life by reducing one’s interest in basic activities and hobbies due to continual feelings of sadness and low self-esteem. Previous studies have proposed that low high-density lipoprotein cholesterol (HDL-C) levels play a key role in depression because of changes in serotonin and lipid metabolism. There is little research on how depression is affected … Continue reading Depression May Be Linked To Specific Lipid Ratios Within The Body

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2021-22, Psychology

The Effects of Social Anxiety on Decision-Making and Recognition of Facial Expressions

Joyce Chen ’23 Facial expressions are one of the fundamental methods by which we perceive others. However, our perceptions can be faulty. Perceptual decision-making for recognizing facial cues is biased by our personal attitudes, social knowledge, and stereotypes. Despite there being numerous studies on this process, not much is known about how perceptual decision-making occurs in individuals with anxiety symptoms. Dr. Aprajita Mohanty, a Stony … Continue reading The Effects of Social Anxiety on Decision-Making and Recognition of Facial Expressions

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2021-22, discovery

Reprogramming Cells May Reverse the Aging Process

Sooraj Shah ’24 Aging is a natural process by which cells are progressively unable to divide as efficiently as before, causing cell death and lysis as the functions of the cell slowly begin to decline. The main contributor to this are the telomeres at the end of our chromosomes. Telomeres get shorter as cells divide because replication cannot copy the “lagging end” of the chromosome. … Continue reading Reprogramming Cells May Reverse the Aging Process

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2021-22, Brain

Thalamocortical Associated Brain Injuries May be Linked to Behavioral Changes

Sooraj Shah ’24 The discussion of brain injury, particularly in contact sports such as boxing or football, has grown in importance as more and more former athletes speak out on the lingering effects years after retirement. The discovery of CTE (chronic traumatic encephalopathy) in 2002 marked the beginning of increased attention and research into traumatic brain injuries (TBI). While CTE was found to spread throughout … Continue reading Thalamocortical Associated Brain Injuries May be Linked to Behavioral Changes

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2021-22, Cellular and Molecular Science, Depression, Neuroscience

Loss of NG2 Glia Implicated in Emergence of Depression Symptoms

Vignesh Subramanian ’24 Glia are non-neuronal cells that host and provide a number of homeostatic ancillary functions in both the central (CNS) and peripheral (PNS) nervous systems. Though only recently discovered and characterized, glial cells vastly outnumber neurons and provide them with structural support and insular protection, driving their myelination (the process of forming coverings known as myelin sheaths that coat neurons’ signaling axons), facilitating … Continue reading Loss of NG2 Glia Implicated in Emergence of Depression Symptoms

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2021-22, Cellular and Molecular Science, Neuroscience

Stabilization of BBB Junction Protein Attenuates Epileptic Brain Activity

Vignesh Subramanian ’24 Epilepsy is a chronic central nervous system disorder characterized by abnormal neuronal activity in the brain that triggers repeated, spontaneous seizures. Treatment-resistant epilepsy has previously been linked to disruption of the blood-brain barrier (BBB), a semipermeable network of close-packed endothelial (border) cells and capillaries that controls the influx of solutes circulating in the bloodstream into the extracellular fluid of the brain. The … Continue reading Stabilization of BBB Junction Protein Attenuates Epileptic Brain Activity

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2021-22, Depression, Health, mental health

The Effect of Coffee and Caffeine on Healthcare Workers in Iran

Yukta Kulkarni ’22 Coffee, specifically the consumption of caffeine, is prevalent across the world. When studying the effects of caffeine on psychological disorders, previous studies have led to inconclusive results. However, most of the research has been completed in Western and first-world countries. Since there are differences in culture and nutrition in varying regions, it is important to see the effects of caffeine in other … Continue reading The Effect of Coffee and Caffeine on Healthcare Workers in Iran

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2021-22, Cancer, Cellular and Molecular Science, Health and Medicine

A New Treatment Can Reprogram Macrophages to Kill Cancer Cells

Yukta Kulkarni ’22 Cancer is a disease in which there is uncontrollable cell growth in any part of the body. The migration of the cancer cells from the origin to other parts of the body is called metastasis, causing malignant tumors. Cancerous cells can be aided by other cells found in tissues such as tumor-associated macrophages (TAMS) that stimulate tumor growth, prompt metastasis, and promote … Continue reading A New Treatment Can Reprogram Macrophages to Kill Cancer Cells

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