Category: Degenerative Disease

Brain, Cognition, Degenerative Disease, General Neuroscience, Neurology

Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

Author: Kang Lai, Class of 2026 Functional hyperemia, or the dilation of blood vessels in response to increased metabolic activity, is critical for regulating the levels of oxygen and glucose in the brain. Moreover, it facilitates the clearance of metabolic byproducts such as amyloid-β peptide (Aβ), an accumulation of which underlies Alzheimer’s disease. In Alzheimer’s Disease (AD), disruptions in vascular dynamics are significant but poorly … Continue reading Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

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2024-25, Cognition, Degenerative Disease, Disease, General Neuroscience, Health, Health and Medicine

Green Tea: Fighting Dementia One Cup at a Time

Sean Krivitsky, Class of 2026 Dementia is a progressive neurological disease most prevalent in older adults that is associated with aging and significant declines in cognitive function and memory. It has been strongly correlated with general brain atrophy, including of the hippocampus, and the increased presence of lesions (areas of damage within brain tissue) in cerebral white matter. This corresponds to the symptoms observed in … Continue reading Green Tea: Fighting Dementia One Cup at a Time

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2024-25, Biology, Degenerative Disease, General Neuroscience, Neuroscience

Neurogenesis and Repair Mechanisms Following Traumatic Brain Injury: Insights from Mouse Models

Kang Lai, Class of 2026 Traumatic Brain Injury (TBI) is one of the most common causes of cognitive defects affecting both physical and mental functions of the brain. Its implications span from cognitive defects to motor dysfunction to behavioral disorders–all of which permanently and severely diminish quality of life. TBI also greatly disrupts neurogenesis–the formation of new neurons– and neuronal stem cell regeneration. At the … Continue reading Neurogenesis and Repair Mechanisms Following Traumatic Brain Injury: Insights from Mouse Models

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2024-25, Degenerative Disease, Disease, Health, mental health, Psychology

Can a Change in Diet Improve Non-Motor Symptoms in Parkinson’s Patients?

Asher Agarwal, Class of 2027 Parkinson’s disease (PD), the second most prevalent neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra, a region important for the modulation of motor control. The classic triad of Parkinson’s symptoms is tremors, rigidity, and bradykinesia (slowness of movement). Recent research has been investigating the gastrointestinal (GI) symptoms associated with Parkinson’s. Evidence suggests the existence … Continue reading Can a Change in Diet Improve Non-Motor Symptoms in Parkinson’s Patients?

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2024-25, Degenerative Disease, Neuroscience, Psychology, Technology

The Joystick of the Mind: The Quest of Battling Dementia

Author: Sajia Athai, Class of 2026 Figure 1. Pictures on a map representing memories. People often fear the likelihood of their relatives and friends struggling to remember them as they age. From diseases such as Alzheimer’s to dementia, patients all over the world often struggle with the detrimental impacts of memory loss and the inability to form new ones.  Previous experiments unveil the impact of … Continue reading The Joystick of the Mind: The Quest of Battling Dementia

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2024-25, Chemistry, Degenerative Disease, Disease, Molecular Biology, Neurology, Neuroscience

Lipid Accumulation Found as a Mechanism of Cellular Senescence in Parkinson’s Disease

Author: Asher Agarwal, Class of 2027 Figure 1. A man assisting an old patient with taking their medication. Parkinson’s Disease (PD) is a neurodegenerative disorder associated with neuronal death, specifically of the dopaminergic (DA) neurons in the region of the brain responsible for motor coordination and control. The death of these neurons, most commonly due to aging, causes a classic triad of symptoms: bradykinesia (slow … Continue reading Lipid Accumulation Found as a Mechanism of Cellular Senescence in Parkinson’s Disease

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2024-25, Brain, Degenerative Disease, Disease, mental health, Neuroscience

Amyloid-beta Deposition: A Cause or Byproduct of Alzheimer’s?

Author: Farzad Hoque, Class of 2028 The relationship between neurovascular coupling and Alzheimer’s disease (AD) progression has been a focal point of neurological research. While vascular dysfunction in AD is well-documented, questions remain about whether these abnormalities emerge before amyloid-beta (Aβ) deposition or arise as a consequence. Recent research has shed light on the early neurovascular changes in mouse models of AD, suggesting new mechanisms … Continue reading Amyloid-beta Deposition: A Cause or Byproduct of Alzheimer’s?

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2024-25, Brain, Degenerative Disease, General Neuroscience, Neuroscience

EEG Wave Value Differentiation Explaining Different Stages of Parkinson’s Disease

Author: Ishmam Khan, Class of 2025 Figure: Parkinson’s is a detrimental neurodegenerative disease that affects patients at varying degrees of severity As neurodegenerative diseases like Parkinson’s disease (PD) progress, insights into brain changes become crucial for early diagnoses and effective interventions. In a recent study, Pappalettera et al. at Stony Brook University utilized Approximate Entropy (ApEn) analysis to compare the complex brain signals that occur … Continue reading EEG Wave Value Differentiation Explaining Different Stages of Parkinson’s Disease

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Brain, Degenerative Disease, General Neuroscience

Prolonged Functional Hyperemia Found in Early Stage AD in mouse models

By Asher Agarwal, Class of 2027 When a region of our brain is active, blood vessels dilate to increase blood flow and meet the increased metabolic demand of the area. This is known as functional hyperemia, or neurovascular coupling, and it is critical for maintaining metabolic homeostasis in the brain. Previous research has shown that, in response to novel environments, hippocampal inhibitory interneurons are stimulated … Continue reading Prolonged Functional Hyperemia Found in Early Stage AD in mouse models

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2023-24, 2023-24, Brain, Cellular and Molecular Science, Degenerative Disease, General Neuroscience, Molecular Biology, Neurology, Neuroscience, Year

Mature Oligodendrocytes Demonstrate Delayed Cell Death by Alternate Mechanism

By Vignesh Subramanian, Class of 2024 Figure 1: A myelinating oligodendrocyte in a murine brain.  Oligodendrocytes are specialized glial cells in the central nervous system primarily responsible for myelination, the process of ensheathing the axons of neurons in a lipid-rich membrane known as myelin, which insulates the nerve fibers and speeds up the transmission of the action potentials they conduct. Oligodendrocytes are the products of … Continue reading Mature Oligodendrocytes Demonstrate Delayed Cell Death by Alternate Mechanism

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2023-24, Brain, Chemistry, Degenerative Disease, Disease, General Neuroscience, Health and Medicine

Uncovering a Novel Biomarker For The Identification of Parkinson’s-Related Diseases

Author: Sean Krivitsky, Class of 2026 Parkinson’s disease is a severe neurodegenerative disorder most commonly occurring in late adulthood. It is primarily characterized by motor dysfunctions such as uncontrollable tremors and stiffness. Since there is no conclusive test for diagnosis of the disorder, neurologists rely on a comprehensive evaluation system, combining symptoms and physical assessments to gauge the likelihood that an individual has Parkinson’s. A … Continue reading Uncovering a Novel Biomarker For The Identification of Parkinson’s-Related Diseases

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Biology, Cellular and Molecular Science, Degenerative Disease, discovery, General Neuroscience, Health and Medicine, Neuroscience

Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

Author: Vignesh Subramanian, Class of 2024 Figure 1: Barnes maze tests were performed to assess the spatial reference memory of the knock-in AD mouse models. Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by significant memory loss and cognitive decline that worsen with age. While the disease’s long-established hallmarks include the aggregation of two misfolded proteins known as beta-amyloid and phosphorylated tau, recent research … Continue reading Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

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