Category: Drug Discovery

Biology, Cancer, Drug Discovery, Health and Medicine

Battlefront: The Nano DLC

By Farzad Hoque, Class of 2028 On the battlefield, the adjacent role of nanocarriers is logistical. They provide munitions support and focused attention to the battlefield. In the body, the focus is on how these nanocarriers can improve the fight against cancer–specificity, reduce toxicity, and sustain the efficacy of immunological agents–all by modulating the antitumor immune response. In prior wars with cancer, the body’s arsenal … Continue reading Battlefront: The Nano DLC

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Biology, Cellular and Molecular Science, Drug Discovery

Exploring Drug Repurposing for Lacunar Stroke Prevention

Author: Kimberly Johnston ’26 Drug repurposing is a strategy that aims to find new applications for drugs that have already been proven safe and effective in humans. Lacunar stroke, characterized by reduced blood flow to the deep structures of the brain, can significantly impair a person’s movement, speech, and cognitive functions. Preventative treatments typically focus on managing hypertension, diabetes, and high cholesterol as these conditions … Continue reading Exploring Drug Repurposing for Lacunar Stroke Prevention

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Brain, Drug Discovery, General Neuroscience, Health and Medicine, Neuroscience

AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

Vignesh Subramanian ’24 Figure 1: The South Pool of the 9/11 Memorial in New York, New York Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive thinking skills that typically worsens with age, and is the leading cause of dementia. Key hallmarks of the disease include buildups of two particular proteins – beta-amyloid peptide and phosphorylated tau – … Continue reading AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

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Drug Discovery, Pharmacology, Psychology

Microglial Depletion Promotes Maternal Behavior in Nulliparous Rats

Vignesh Subramanian ’24 The period during and immediately following childbirth, known as the peripartum period, is marked by major changes in the mother’s hormone levels, immune function, and neurological activity. These changes include structural brain alterations with a significant impact on postpartum behaviors, such as maternal-infant bonding, that are essential for the well-being of the offspring. Many neuroimmune alterations emerging in late pregnancy remain unclear … Continue reading Microglial Depletion Promotes Maternal Behavior in Nulliparous Rats

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Drug Discovery, Evolution, Health and Medicine, Natural World

Is Eternal Life Actually Possible? New Drug Formula May Reverse Biological Age

Joyce Chen ’23 Biological age is the measurement of the true ages of humans through the chemical changes in their DNA. Previous research and hypotheses inferred that reversing this can allow humans to acquire better immune systems and healthier bodies in general. To test if biological age reversal is actually possible, determined scientists from Intervene Immune and the University of California, Los Angeles, completed a … Continue reading Is Eternal Life Actually Possible? New Drug Formula May Reverse Biological Age

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Cognition, Drug Discovery

Long-Term Use of These Drugs May Increase Risk for Dementia

Nicole Zhao ’20 A diagnosis of dementia is often accompanied by fear, anxiety and the need to fulfill a bucket list before the condition robs you of life. Dementia is the loss of cognitive functioning which includes thinking, remembering and reasoning (1). These losses then manifest in a change of behavior such as the inability to communicate, change in personality, and eventually the loss of … Continue reading Long-Term Use of These Drugs May Increase Risk for Dementia

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Drug Discovery, Microbiota

New Targeted Therapy May Prevent and Reverse Food Allergies

Nicole Zhao ’20 A food allergy is an immune system reaction that occurs when exposed to a certain food (1). Symptoms resulting from an allergic reaction include digestive problems, hives, swollen airways and even anaphylaxis (1). Anaphylaxis is a serious, life-threatening allergic reaction and encompasses a variety of symptoms with high severity (2). During an allergic reaction, the immune system recognizes that a specific food … Continue reading New Targeted Therapy May Prevent and Reverse Food Allergies

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Cancer, Drug Discovery

Costunolide: A Potential Drug Molecule for Fighting Gastric Cancer

Nomrota Majumder ‘21 Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, is shown to have powerful activity against multiple cancer forms. However, the effects of costunolide has not yet been investigated with gastric cancer, or the formation and growth of malignant cancer cells lining the stomach. As the fifth most common cancer in the world, and the third leading cause of cancer related death in … Continue reading Costunolide: A Potential Drug Molecule for Fighting Gastric Cancer

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Drug Discovery, Synthetic Biology

A Pill that Mimics the Immune System

By Anirudh Chandrashekar The role of Y-shaped antibodies to fight viruses, bacteria and different forms of cancers is a heavily researched field.  For many years, researchers have sought to develop and optimize antibodies and other protein-based therapies to supplement and  revitalize the host’s defense system. At the same time, these antibodies have multiple drawbacks; antibodies are generally extremely bulky and need to be administered intravenously. To … Continue reading A Pill that Mimics the Immune System

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