Simran Kaur ‘20 Kidney fibrosis, the accumulation of excess tissue, is the last pathway in end-stage renal failure. Examination of kidneys afflicted with renal disease in both animal and human models has shown a defect in the function of mitochondria. Mitochondria are responsible for the production of energy (ATP) in the cell, funding the processes of toxic waste removal from the blood and the regulation … Continue reading Role of Mitochondrial Gene TFAM in The Progression of Renal Disease
By Ellie Teng ‘21 Fasting is an ancient component in numerous religions and cultures. Individuals seeking weight loss often practice fasting, making it a prominent topic in the nutrition field. A team of scientists from the Okinawa Institute of Science and Technology Graduate University and Kyoto University recently found that fasting comes with innumerable health benefits. Blood samples from four healthy individuals who fasted for … Continue reading Metabolic Reactions Activated During 58-hour Fasting
By Ellie Teng ‘21 A prominent protein in cancer research, p53, is known for its cancer fighting abilities. p53 suppresses the initiation of tumor growth by inhibiting the cancer metabolic switch from oxidative phosphorylation to glycolysis. Glycolysis is attributed to cancer metabolism and is required for tumorigenesis, or the formation of tumors. Essentially, p53 protects the genome against mutations and prevents the mutations from being … Continue reading Protein WTp53: Fights Tumors or Boosts Cancer?
Samara Khan ‘19 The process of human aging is generally considered to be inevitable. As we become older, the collagen and elastin in our skin breaks down, causing fine lines and wrinkles to form. Our bodies stop producing melanin, and our hair turns gray and eventually falls out. While there are many cosmetic products that can improve the appearance of sagging skin and thinning hair, … Continue reading Can Common Signs of Aging be Reversed?
By Meghan Bialt-DeCelie ’19 The respiratory function of the mitochondrion, the energy producing organelle found in the cell, can decline over time. This is because of how the mitochondrion enlarge and assume a more elongated shape. Typically, that mitochondrion will eventually break down and get removed processes called mitochondrial fission and mitophagy respectively. Accumulation of the ineffective mitochondria and inability to remove them are major … Continue reading Controlling Mitochondria to Stop the Clocks
by Aaron Gochman (’18) Mitochondria are known as the “powerhouse of the cell.” They provide energy and regulate important biological processes to ensure healthy metabolism and proper cellular function. Hence when mitochondrial dysfunction occurs, the cell is at great risk. A pair of researchers from University of Gothenburg in Sweden have characterized a pathway in which harmful mitochondrial proteins can be degraded without affecting normal … Continue reading Mitochondria: Selective protein degradation ensures cellular longevity