Author: Young Investigators Review

The Young Investigators Review is Stony Brook University's undergraduate-oriented, all-inclusive science journal. Founded in 2008, our mission is to provide the student community with a way to learn more about the research currently being done on-campus by their faculty and fellow peers. We feature articles that span all fields, from Physics to Neuroscience, as well as original student research reports straight from the campus laboratories. Our journal offers aspiring talented future researchers and physicians a way to hone their science writing skills and spread word of their experiences to inspire incoming students to think about devoting their futures to the various fields of science.
Chemistry, Environment, Natural World

Herbaceous Layer Dynamics in Central Appalachian Hardwood Forests

Fatin Chowdhury ’20 Forests are stratified in sections such as the herbaceous layer, which includes tracheophytes (plants with vasculature) over 1 meter in height and can be extremely ecologically significant. Potential factors influencing forest dynamics in this context include top layer (overstory) characteristics and soil quality. A researcher at the University of West Florida, Frank S. Gilliam, recently conducted work at the Fernow Experimental Forest … Continue reading Herbaceous Layer Dynamics in Central Appalachian Hardwood Forests

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Biology, Psychology, Sociology

How Do We Recognize Dog Emotions?

Ayesha Azeem ‘23 We humans are very complex creatures. When we spend a lot of time in close association with a species, we tend to treat them as if they are humans as well, and we can decipher their emotions clearly. With the expression of emotions, we can communicate our motivations, responses and needs to others. Recognizing animals’ emotions can be beneficial, as it may … Continue reading How Do We Recognize Dog Emotions?

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Brain, Cellular and Molecular Science, General Neuroscience, Sociology

Genetics and the Brain

Ayesha Azeem ‘23 Our society currently witnesses an underrepresentation of females in most ‘heavy’ science and mathematics fields, including technology and engineering. Though some may argue that the unfair proportions are due to biological differences, little evidence supports this claim. Scientists study biological differences in the brain, and the brains of males and females are more similar than not. Though behavioral studies often find no … Continue reading Genetics and the Brain

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Biology, General Psychology, Health and Medicine, Sociology

How Relaxing Music Affects Sleep

Ayesha Azeem ‘23 Sleep is vital for maintaining physical and mental health and general well-being. However, our society often witnesses sleep disturbances, especially as we get older and in those who suffer from psychological disorders. However, many people, especially the elderly or those suffering from psychological disorders, experience sleep disturbances. Though some may use sleep-inducing medication, this may not be as effective as toleration can … Continue reading How Relaxing Music Affects Sleep

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Health and Medicine, Pharmacology, Sociology

Open-Label Placebos and Test Anxiety

Ayesha Azeem ‘23 Test anxiety is a condition that affects up to 40% of students who suffer immense stress and worry before and while taking a test. Anxiety in test situations can present itself in many different ways and  may not seem so apparent to the sufferer at first. Symptoms include: nervousness, high heart rate, sweating, avoidance, and failing concerns. Anxiety can weaken the ability … Continue reading Open-Label Placebos and Test Anxiety

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Cell Cycle, Cellular and Molecular Science, Health

Bacteriophages as Therapeutic Targets in the Alleviation of Alcoholic Liver Disease Symptoms

Simran Kaur ‘20 The acute form of alcohol-induced liver disease, alcoholic hepatitis, has a high mortality rate, and therapy is insufficiently effective. It is known to be promoted by gut microbiota. Cytolysin, a cell-destroying substance secreted by Enterococcus faecalis, is a major cause of hepatocyte apoptosis, consequent liver injury, and progression of hepatic disease. Patients diagnosed with alcohol-dependence present with significantly higher concentrations of E. … Continue reading Bacteriophages as Therapeutic Targets in the Alleviation of Alcoholic Liver Disease Symptoms

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Biology, Brain, General Neuroscience, Neuroscience

Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

Simran Kaur ‘20 All living organisms have circadian rhythms, an approximately twenty-four cycle that ensures the appropriate timing of important physiological functions such as digestion and sleep. Glioblastoma stem cells (GSCs) that are involved in the formation of aggressive brain tumors are stimulated by altered circadian clocks. Clock genes are responsible for the oscillation of gene expression within the day and can behave as both … Continue reading Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

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Cellular and Molecular Science, Degenerative Disease, Health and Medicine

Engineered T-cells as a Target for Fibrosis in Myocardial Disease

Simran Kaur ‘20 Fibrosis, the excessive deposition of extracellular matrix by fibroblasts into cardiac tissue, is a significant process in the development of cardiac disease and subsequent cardiac failure, but there are not many clinical treatments that can effectively target it. Cardiac fibroblasts express an antigen that can be targeted by the transplantation of antigen-specific CD8+ T-cells because CD8+ T-cells are involved in the inflammatory … Continue reading Engineered T-cells as a Target for Fibrosis in Myocardial Disease

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Cellular and Molecular Science, Medicine and Physiology, Molecular Biology

CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

Simran Kaur ‘20 CRISPR-Cas9 technology has been used to edit the mammalian genome for decades, allowing scientists to remove, add, and change sections of DNA sequences. The human immunodeficiency virus (HIV) does not have a cure that exists, but studies have shown that allogeneic transplantation of STEM cells into diagnosed patients can eradicate the virus. CCR5 is the coreceptor for the entry of HIV into … Continue reading CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

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Biology, Physics and Technology, Technology

The Future of 3D Printing in Biotechnology

Aditi Kaveti ‘23 Health technology has advanced tremendously, especially in the field of tissue engineering. Two main products that have resulted from tissue engineering are scaffolds and hydrogels, both being distinct physical forms of polymers for tissue engineered skin. To  enhance cell interaction with polymers, cells need to be present as integrated parts of the bioengineered tissue or host cells need to be recruited for … Continue reading The Future of 3D Printing in Biotechnology

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