Category: Cellular and Molecular Science

2024-25, Chemistry, Degenerative Disease, Disease, Molecular Biology, Neurology, Neuroscience

Lipid Accumulation Found as a Mechanism of Cellular Senescence in Parkinson’s Disease

Author: Asher Agarwal, Class of 2027 Figure 1. A man assisting an old patient with taking their medication. Parkinson’s Disease (PD) is a neurodegenerative disorder associated with neuronal death, specifically of the dopaminergic (DA) neurons in the region of the brain responsible for motor coordination and control. The death of these neurons, most commonly due to aging, causes a classic triad of symptoms: bradykinesia (slow … Continue reading Lipid Accumulation Found as a Mechanism of Cellular Senescence in Parkinson’s Disease

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2024-25, Biology, Cellular and Molecular Science, Chemistry, Embryonic Development, Genetics, Molecular Biology

Novel Insights Into the Mechanism of DSB Repair During Meiosis Crossover Events

Author: Sean Krivitsky, Class of 2026 Figure 1. Image of cells at various stages of meiosis. Meiosis is a key process underlying sexual reproduction and is responsible for the production of gametes, sperm, and eggs, which are necessary for fertilization. One important aspect of meiosis is that it contributes to the process of genetic diversification through genetic recombination, which involves the crossing over and independent … Continue reading Novel Insights Into the Mechanism of DSB Repair During Meiosis Crossover Events

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2024-25, Biology, Cellular and Molecular Science, Molecular Biology, Neurology, Psychology

Back Like They Never Left: How the Remnants of Ancient Viruses May Affect the Progression of Neurological Disease

Author: Luis Caseñas, Class of 2026 Figure 1: Amyotrophic Lateral Sclerosis (ALS) is a neurological disease that triggers the degeneration of one’s Central Nervous System. Specifically, ALS targets motor neurons (pictured above) essential to muscle control and coordination. Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that targets motor neurons in the Central Nervous System. This degeneration inevitably leads to gradual loss of muscle control … Continue reading Back Like They Never Left: How the Remnants of Ancient Viruses May Affect the Progression of Neurological Disease

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2024-25, Biology, Genetics, Health

Unraveling Chronological Age: Epigenetic Modifications as Indicators of Cognitive Decline

Author: Tiffany Ang, Class of 2025 Figure 1: A visualization of epigenetic modifications that shape gene expression without changing the genetic code. DNA methylation-derived epigenetic clocks are powerful tools for assessing biological aging and age acceleration–the difference between biological and chronological age. Unlike chronological age, which fails to capture the impact of biological and environmental influences, age acceleration explains individual differences in cognitive functions such … Continue reading Unraveling Chronological Age: Epigenetic Modifications as Indicators of Cognitive Decline

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2024-25, Cellular and Molecular Science, Chemistry, Molecular Biology

FOXO1: A Memory Upgrader for T-cells!

Author: Farzad Hoque, Class of 2028 The persistence and effectiveness of chimeric antigen receptor (CAR) T-cell therapies depend significantly on the ability of these cells to maintain memory-like states while avoiding exhaustion. Recent research has identified the transcription factor FOXO1 as a critical regulator of memory programming in CAR T cells, offering transformative insights into improving therapeutic outcomes. Alexander E. Doan and colleagues conducted a … Continue reading FOXO1: A Memory Upgrader for T-cells!

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2024-25, Cancer, Cellular and Molecular Science, Chemistry, discovery, Health, Health and Medicine, Medicine and Physiology

Utilizing the Principle of Pro-Cancer Properties of Antioxidants to Treat Prostate Cancer

Author: Sean Krivitsky, Class of 2026 Figure 1. Depiction of various foods that are commonly associated with having antioxidant properties.Prostate cancer (PC) has become a growing concern for men as its rate of incidence has been steadily increasing by more than 3% per year for the past decade. As a result, many have been searching for various treatments and interventions during PC progression to help … Continue reading Utilizing the Principle of Pro-Cancer Properties of Antioxidants to Treat Prostate Cancer

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2024-25, Biology, Cancer, Cell Cycle, Cellular and Molecular Science, Chemistry, Health and Medicine, Molecular Biology

Understanding the Mechanisms of the Leading Cause of Death in Cancer Patients

Author: Sean Krivitsky, Class of 2026 Figure 1. Animated representation of the release of cytokines in the extracellular environment. Cancer is a disease that wreaks devastation on the bodies of the patients it afflicts. Cancerous tumor cells lead to the sickness observed in cancer patients in a variety of ways, but one of the primary causes of cancer-related sickness and death is referred to as … Continue reading Understanding the Mechanisms of the Leading Cause of Death in Cancer Patients

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2023-24, 2023-24, Brain, Cellular and Molecular Science, Degenerative Disease, General Neuroscience, Molecular Biology, Neurology, Neuroscience, Year

Mature Oligodendrocytes Demonstrate Delayed Cell Death by Alternate Mechanism

By Vignesh Subramanian, Class of 2024 Figure 1: A myelinating oligodendrocyte in a murine brain.  Oligodendrocytes are specialized glial cells in the central nervous system primarily responsible for myelination, the process of ensheathing the axons of neurons in a lipid-rich membrane known as myelin, which insulates the nerve fibers and speeds up the transmission of the action potentials they conduct. Oligodendrocytes are the products of … Continue reading Mature Oligodendrocytes Demonstrate Delayed Cell Death by Alternate Mechanism

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2023-24, Cancer, Cellular and Molecular Science, Genetics, Health and Medicine

Mysterious Long Non-Coding RNAs Revealed as Playing a Role in Gastric Cancer

Author: Sean Krivitsky, Class of 2026 To the astonishment of many, nearly 99% of the human genome consists of non-coding regions that are not transcribed into mRNAs for protein synthesis. However, some of those non-coding regions of DNA can be transcribed into various types of non-coding (nc) RNAs, including long ncRNAs. Until recently, the scientific community believed these ncRNA products to be functionally irrelevant, playing … Continue reading Mysterious Long Non-Coding RNAs Revealed as Playing a Role in Gastric Cancer

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Biology, Cellular and Molecular Science, Degenerative Disease, discovery, General Neuroscience, Health and Medicine, Neuroscience

Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

Author: Vignesh Subramanian, Class of 2024 Figure 1: Barnes maze tests were performed to assess the spatial reference memory of the knock-in AD mouse models. Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by significant memory loss and cognitive decline that worsen with age. While the disease’s long-established hallmarks include the aggregation of two misfolded proteins known as beta-amyloid and phosphorylated tau, recent research … Continue reading Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

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2023-24, Cellular and Molecular Science, General Neuroscience, Genetics, Neurology, Neuroscience

Uncovering a Key Mechanism of Rett Syndrome Pathology

Author: Sean Krivitsky, Class of 2026 Rett syndrome (RTT) is a severe neurological disorder found primarily in females that causes impairment in essential functions including breathing, eating, and walking abilities. The disorder is characterized by slowed brain growth, which can lead to various mental and physical disabilities. Key markers and causes of RTT are mutations on a gene called MECP2. MECP2 is an X-linked gene … Continue reading Uncovering a Key Mechanism of Rett Syndrome Pathology

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2023-24, Cancer, Cellular and Molecular Science, Disease, Health and Medicine, Molecular Biology

Linking Key Immune System Components to Cancer Progression

Author: Sean Krivitsky, Class of 2026 Breast cancer is the most frequently diagnosed form of cancer in the world and is one of the leading causes of cancer-related deaths. Triple-negative breast cancer (TNBC), a common type of breast cancer, is fast-growing and is associated with consistent poor prognosis. Unlike several other types of breast cancer, TNBC possesses a unique pathogenic mechanism, which means that it … Continue reading Linking Key Immune System Components to Cancer Progression

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