Sleep and Its Impact on Alzheimer’s Disease
By Meghan Bialt-DeCelie ’19 A good night’s rest is hard to come by these days, however a study led by Yo-El S. Ju MD from Washington University suggests that it is more important than one may realize. They found that inadequate sleep causes the Alzheimer’s related protein, amyloid beta, to increase. They tested the amyloid beta levels from the cerebral spinal fluid of 22 middle … Continue reading Sleep and Its Impact on Alzheimer’s Disease
Tardigrade and Its Impact on Survivability
By Meghan Bialt-DeCelie ’19 Whether the world ends in asteroids or radiation, the big question is what, if anything, will survive. Researchers lead by Dr. David Sloan from the University of Oxford assessed the resilience of species when against three astrophysical catastrophes (asteroids, supernovas, and gamma-ray bursts) that could sterilize the planet. Â These events threaten the survival of species with radiation and by deterioration of … Continue reading Tardigrade and Its Impact on Survivability
The Anti-CRISPR
By Meghan Bialt-DeCelie ’19 Since the explosion of CRISPR-Cas 9, a gene editing technology, researchers have been further exploring its mechanisms and ways of improving the system. AcrIIA4 is a known anti-CRISPR protein that inhibits the CRISPR-Cas 9 complex, but the mechanism and residues involved were not as explored. Researchers lead by Jiyung Shin, PhD from The University of California Berkley investigated AcrIIA4 to … Continue reading The Anti-CRISPR
Cancer Therapy Employing Lipid-coated Gold Nanorod
By Rideeta Raquib ’19 Gene regulation induced by light has potential for noninvasive control over the function of target cells. One such method involves the delivery of photothermal heaters and heat shock protein (HSP) promoter-driven protein expression vectors into the cells and then illuminating them to activate the cells. HSP promoters are controlled by heat shock factor, which is a transcription factor in the cytosol … Continue reading Cancer Therapy Employing Lipid-coated Gold Nanorod
Novel Findings to Tackle Malaria
By Rideeta Raquib ’19 Malaria is a deadly disease caused by single-celled parasites of the genus Plasmodium. Once the body is infected, sporozoites migrate to the liver and replicate to merozoites. A sporozoite in a motile, sporelike phase during a parasite’s asexual reproduction. A merozoite is the growth stage, which occurs in the bloodstream. The toxins released by merozoites destroy red blood cells and can … Continue reading Novel Findings to Tackle Malaria
Music Affects Brain Structure
By Rideeta Raquib ’19 Whether it be going out for a jog or driving a car, our day-to-day physical movements are often coordinated with music. Recently, researchers have harnessed music and employed auditory cues in response to musical stimuli to enhance movement learning and rehabilitation. Previous studies have shown that musicians tend to have a higher fractional anisotropy (FA) values than non-musicians. FA is a … Continue reading Music Affects Brain Structure
Neutrophilic Pleocytosis is Connected to Viral CNS Infections
By Caleb Sooknanan ’20 Viral central nervous system (CNS) infections are often associated with cerebrospinal fluid (CSF) lymphocytic pleocytosis, or an increase in the fluid’s white blood cell count. However, these infections are also connected to neutrophilic pleocytosis, an increase in the fluid’s neutrophil count. The clinical and prognostic significance of CSF neutrophilic pleocytosis remains unknown in patients. Doctor Siraya Jaijakul and researchers at the … Continue reading Neutrophilic Pleocytosis is Connected to Viral CNS Infections
Capsule Robots Can Be Used for Biosensor Implantation
By Caleb Sooknanan ’20 Biosensors have become increasingly practical within the medical field, as they can detect different biometrics such as heart rate and body temperature levels. However, current biosensors can wear out quickly and elicit health problems such as trauma. Many efforts — especially in the area of capsule robotics — have been made to develop biosensors that are noninvasive and effective at monitoring … Continue reading Capsule Robots Can Be Used for Biosensor Implantation
Arthropod Toxins Used to Engineer Mosquito-Killing Fungi
By Caleb Sooknanan ’20 Mosquitoes are known to transmit potent diseases — particularly malaria and dengue fever — among humans. The impact of these diseases is most apparent in sub-Saharan Africa, where over 200 million cases of malaria are reported annually. Many disease control programs in the region have used broad-spectrum insecticides to eliminate mosquitoes and reduce the spread of vector-borne diseases. However, malarial mosquitoes … Continue reading Arthropod Toxins Used to Engineer Mosquito-Killing Fungi
Parent and child cortisol levels show concordance in certain conditions
Aaradhana Natarajan, 2020 The hypothalamus-pituitary-adrenal axis, or HPA axis, is a neuroendocrine pathway that is linked to emotional functioning and health. Researchers at the University of Maryland College Park, led by Dr. Stephanie Merwin, recently investigated whether or not the HPA axis functioning of a child showed correlation to that of their parents. They accounted for both the child’s temperament and parent’s psychological history in … Continue reading Parent and child cortisol levels show concordance in certain conditions
Perinatally acquired HIV associated with lower regional grey matter volume
Aaradhana Natarajan, 2020 The Human Immunodeficiency Virus, commonly called HIV, is one of the most widespread immune disorders across the globe. It weakens the immune system by reducing lymphocyte count and increasing susceptibility to other diseases. While it is most commonly known for its transmissibility, it is also possible for HIV-positive pregnant women to pass on the infection to their offspring. This form of HIV … Continue reading Perinatally acquired HIV associated with lower regional grey matter volume
Sleep disturbances may play a role in Alzheimer’s pathogenesis
Aaradhana Natarajan, 2020 Alzheimer’s Disease is a neurodegenerative condition that has recently become a popular focus for research. As a result, scientists are now aware that the accumulation of amyloid-β-peptide oligomers (AβOs) play a central role in Alzheimer’s pathogenesis. However, the effect of sleep disturbances on Alzheimer’s risk is relatively underknown. This knowledge gap spurred Dr. Grasielle Kincheski and her team at the Federal University … Continue reading Sleep disturbances may play a role in Alzheimer’s pathogenesis
Young Investigators Review 