Category: Health and Medicine

Cancer, Health and Medicine

Exploiting Replication Fork and Checkpoint Mechanisms: ATR Signaling and Checkpoint Inhibitors Unveil New Avenues for Targeting Cancer Replication Stress

Justin Lim ’26 Figure 1: Breast cancer cells (1).jpg Cancer, a group of diseases characterized by uncontrolled and abnormal cell growth, is generally recognized by its genomic instability built up by bypassing important biological checkpoints. These checkpoints are scattered throughout a cell’s growth period to limit the amount of DNA replication errors and other deleterious mutations during cell division. Due to the evasion of growth … Continue reading Exploiting Replication Fork and Checkpoint Mechanisms: ATR Signaling and Checkpoint Inhibitors Unveil New Avenues for Targeting Cancer Replication Stress

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Biology, Cancer, Health and Medicine, Molecular Biology

Exciting New Approach to Targeting the Mitochondria to Fight Cancer

Sean Krivitsky ‘27 Figure 1. Visualization of the mitochondria Unbeknownst to many, the mitochondria plays a significant role in carcinogenesis given the importance of metabolic processes in the formation and maintenance of tumors. CPI-613, more commonly known as devimistat, is a recently developed drug that targets a key metabolic cycle that takes place in the mitochondria of cancer cells, the tricarboxylic acid (TCA) cycle. The … Continue reading Exciting New Approach to Targeting the Mitochondria to Fight Cancer

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Biology, Health and Medicine, Molecular Biology

Improved initial assessments of severe skin burns allow for more accurate assertion of whether or not surgical intervention is required for healing

Maria Sazonova ’26  Burn injuries can result in significant skin necrosis and deep tissue damage. Severe skin burn injuries are dynamic and hard to predict; therefore, initial assessment is paramount because it forms the basis for a subsequent treatment plan. A group of Stony Brook University scientists led by M. Hassan Arbab, funded by The National Institute of General Medical Sciences, created a neural network … Continue reading Improved initial assessments of severe skin burns allow for more accurate assertion of whether or not surgical intervention is required for healing

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Brain, Drug Discovery, General Neuroscience, Health and Medicine, Neuroscience

AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

Vignesh Subramanian ’24 Figure 1: The South Pool of the 9/11 Memorial in New York, New York Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive thinking skills that typically worsens with age, and is the leading cause of dementia. Key hallmarks of the disease include buildups of two particular proteins – beta-amyloid peptide and phosphorylated tau – … Continue reading AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

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Health, Neurology, Neuroscience, Psychology

Where Do We Feel Love?

Julia Chivu ‘ 23 Figure 1  A person looking off to the side while clutching a neon red heart in a dimly lit environment.  Love has compelled psychologists, philosophers, neuroscientists, and other scholars to try and understand its complexities and implications. Researchers from Aalto University sought to understand how 27 different types of love, including parental, romantic, sexual, and religious love, are perceived and experienced … Continue reading Where Do We Feel Love?

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Health and Medicine, Neuroscience

Nicotine exposure discovered to block aromatase activity in healthy women

Jessica George ’24 Figure 1 Nicotine use disorder has a profound impact on hormones, yet sex differences are poorly understood. Maintaining a harmonious sex-hormone balance is essential for the optimal functioning of the body, as it regulates a wide range of physiological processes. Aromatase serves as the critical enzyme responsible for the conversion of androgens into estrogens, a process fundamental to functions associated with emotional … Continue reading Nicotine exposure discovered to block aromatase activity in healthy women

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Drug Discovery, Pharmacology, Psychology

Microglial Depletion Promotes Maternal Behavior in Nulliparous Rats

Vignesh Subramanian ’24 The period during and immediately following childbirth, known as the peripartum period, is marked by major changes in the mother’s hormone levels, immune function, and neurological activity. These changes include structural brain alterations with a significant impact on postpartum behaviors, such as maternal-infant bonding, that are essential for the well-being of the offspring. Many neuroimmune alterations emerging in late pregnancy remain unclear … Continue reading Microglial Depletion Promotes Maternal Behavior in Nulliparous Rats

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2022-23, COVID-19, Disease, Health and Medicine

Bupropion as a Possible Treatment for COVID-19-Related Brain Fog

Jessica George ’24 The COVID-19 pandemic has affected millions of people worldwide, and many have reported persistent symptoms even after recovery from the initial infection. One of the most common long-term symptoms reported is “brain fog,” a condition characterized by cognitive impairments such as memory loss, difficulty concentrating, and mental fatigue. A recent case series published by Dr. Samuel Reinfeld from the Stony Brook University … Continue reading Bupropion as a Possible Treatment for COVID-19-Related Brain Fog

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2022-23, Cognition, General Neuroscience, Health and Medicine, Uncategorized, Year

Dancing on the Way to Good Health: The Implications for Culturally Relevant Dancing in the Latino Older Adult Population

Peter Gillespie ’25 Figure 1  Merengue, cha-cha cha, bachata, and salsa are four popular forms of dancing that have the potential to increase physical activity, thereby helping to prevent cognitive decline. Physical activity is crucial in improving the health of older individuals. Within the Latino community, there is a rich cultural history of various genres of dance that may help promote  widespread physical activity among … Continue reading Dancing on the Way to Good Health: The Implications for Culturally Relevant Dancing in the Latino Older Adult Population

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2022-23, COVID-19, Health and Medicine, Sociology, Year

Pandemic year brought on exacerbation of race, gender, and geographical disparities of drug overdoses

By: Jessica George, Class of 2024 The opioid epidemic has been a major public health crisis in the United States for several decades; fentanyl, a synthetic opioid, has emerged as a significant contributor to the increase in drug overdose deaths in recent years. Given the prevalence and gravity of this problem, it is imperative to investigate any discrepancies that may exist between populations so as … Continue reading Pandemic year brought on exacerbation of race, gender, and geographical disparities of drug overdoses

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2022-23, Computer Science, Health and Medicine, Physics and Technology, Year

Fighting opioid mortality rates with AI-based forecasts using social media language

By Shahzadi Adeena, Class of 2025 Figure 1:  Pill container laying on counter with cap off The United States has been battling an opioid epidemic for over twenty years, with opioid-related deaths increasing by 350% in this period. A critical obstacle is that the driving force (such as usage of prescription drugs or synthetic opioids) differs within communities and over time. Current methods to follow … Continue reading Fighting opioid mortality rates with AI-based forecasts using social media language

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2022-23, Biology, Medicine and Physiology, Neurology

Development of Innovative Burn Assessment Technique Using Neural Network

Julia Chivu ’23 The current burn injury evaluation methods available for clinical use are ineffective and outdated. These circumstances are problematic as the initial injury assessment is necessary to ensure the best clinical treatment plan for the patient. Burns can lead to deep tissue damages, necrosis, and severe scarring. Without a proper course of action, the injury can negatively impact the patient’s quality of life, … Continue reading Development of Innovative Burn Assessment Technique Using Neural Network

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